Antiviral Prophylaxis with C19 Vaccine? Mucosal Immunity?

2021-07-16: It might be a good idea for fully vaccinated adults to (cautiously) expose themselves to COVID-19 within 2-3 months of becoming fully vaccinated That might give them mucosal immunity. Some of the vaccine elicited antibodies are not effective against the Delta variant, but the very high titers of effective neutralizing antibodies should suffice to prevent severe COVID-19, except very vulnerable population. Of course, clinical trials are needed before recommending this to the public. HCQ + Zinc prophylaxis might be useful before the exposure.

Antiviral Prophylaxis with Vaccine?

2021-07-08. Vaccination decreases innate immunity for some time after the each shot. For COVID-19 in adults, this decrease in the innate immunity is likely compensated by the vaccine-elicited adaptive immunity. This compensation might become sufficiently effective as soon as 10 days after the first shot, although some estimates are longer.

COVID-19 vaccination is conducted in areas where the disease is present, and the person might be already infected in time of vaccination, or become infected within those 10 days. Notice that the vaccine elicited immunity is less effective against the Delta variant, and is likely to be even less effective against future variants.

That suggests that adults getting vaccinated against COVID-19 need to take prophylactic treatment, starting at least a week before the first shot and ending at least a week after it. This measure would also slow down the coronavirus evolution toward vaccine immunity escape.

Research is needed to ascertain that prophylactic drugs do not interfere with the vaccines. Theoretically, Ivermectin and Hydroxychloroquine + Zinc should not interfere with mRNA vaccines. Zinc might interfere with mRNA to spike protein translation in cells, but HCQ+Zn accumulate in lung cells, while most spike protein is produced in lymph nodes.

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